师资队伍
许文燮

基本信息 >>>


  许文燮
  胃肠动力障碍机理研究组
  电话:闵行
  邮箱:wenxiexu@sjtu.edu.cn

研究方向>>>

1、 胃肠动力障碍的机理

2、 平滑肌细胞和ICC的电生理特性

3、 ENS、ICC以及局部胃肠激素功能异常导致胃肠动力障碍的机制

个人简历 >>>

许文燮,研究员,博士生导师,胃肠动力障碍机理研究组组长。

科研项目 >>>

31671192 PAR/SIP在结肠传输功能异常中的新作用及其机制研究 国家自然科学基金(面向) 2017-01~2020-12  70万元   课题负责人

31271236 胃肠平滑肌细胞电重建及其对平滑肌运动的影响及分子机制 国家自然科学基金 2013-01~2016-12  80万元   课题负责人

11232010-A0205 心血管疾病血管重建的力学生物学机制 国家自然科学基金重点 2013-01~2017-12  310万元   子课题负责人

31171107 细胞内H2S/NO 相对平衡在消化道平滑肌运动调控中的作用 国家自然基金 2012-01~2015-12  62万元   课题负责人

10732070 血管细胞分化与迁移的力学生物学机制 国家自然科学基金重点项目 2008-01~2011-12  200万元   课题参与人

10672103 牵张应变对小肠Cajal间质细胞起搏电流的影响及其机制研究 国家自然基金委,面上项目 2007-01~2009-12  41万元   课题负责人

论文与专著 >>>

Mao YL,Shen CL, Zhou T, Ma BT,Tang LY, Wu WT, Zhang HX, Lu HL, Xu WX (通讯作者), Wang ZG   Ablation of Tacr2 in mice leads to gastric emptying disturbance   Neurogastroenterology & Motility   2017   DOI: 10.1111/nmo.13117   

Meng XM, Huang X, Lu HL, Zhang CM, Kim YC, Chen J Xu WX   H2S-induced gastric fundus smooth muscle tension   Exp Physiol   2017   102:779-790   

Zhang CM, Huang X, Lu HL, Meng XM, Liu DH, Kim YC, Xu WX. (通讯作者)   Up-regulation of the Ang II/AT1 receptor may compensate for the loss of gastric antrum ICC via the PI3k/Akt signaling pathway in STZ-induced diabetic mice.   Mol Cell Endocrinol.   2016   423:77-86   

Cai YL,Zhang MH,Huang Xu,Jiang JZ,Piao LH,Jin Z,Xu WX (通讯作者)   CNP-pGC-cGMP-PDE3-cAMP Signal Pathway Upregulated in   Gastroenterology Research and Practice   2015   http://dx.doi.org/10.1155/2015/305258   

Wang ZY, Huang X, Liu DH, Lu HL, Kim YC, Xu WX (通讯作者)   Involvement of Actin Microfilament in Regulation of Pacemaking    Physiol. Res.    2015   65:397-405   

Meng XM, Huang Xu, Zhang CM, Liu DH, Lu HL, Kim YC, Xu WX (通讯作者)   Hydrogen sulfide-induced enhancement of gastric fundus    World J Gastroenterol    2015   21(16): 4840-4851    

1. Liu DH, Huang X, Guo X, Meng XM, Wu YS, Lu HL, Zhang CM, Kim YC, Xu WX. (通讯作者)   Voltage Dependent Potassium Channel Remodeling in Murine Intestinal Smooth Muscle Hypertrophy Induced by Partial Obstruction.   Plos One   2014   9(2): e86109. doi:10.1371.   

Lu HL, Xu Huang, Yi-Song Wu, Chun-Mei Zhang, Xiang-Min Meng, Dong-Hai Liu, Young-chul Kim, Wen-Xie Xu (通讯作者)   Gastric nNOS reduction accompanied by natriuretic peptides signaling pathway upregulation in diabetic mice.    World J Gastroenterol   2014   20():4626-4635   

Liu DH,Huang X,Meng XM, Zhang CM, Lu HL, Kim YC, Xu WX. (通讯作者)   Exogenous H 2 S enhances mice gastric smooth muscle tension through S-sulfhydration of K V 4.3, mediating the inhibition of the voltage-dependent potassium current.   Neurogastroenterol Motil   2014   26():1706-1716   

2. Xu Huang, Xiang-Min Meng, Dong-Hai Liu, Yi-Song Wu, Xin Guo, Hong-Li Lu, Xue-Yan Zhuang , Young-chul Kim, Wen-Xie Xu. (通讯作者)   Different regulatory effects of hydrogen sulfide and nitric oxide on gastric motility in mice.   Eur J Pharmacol   2013   720: 276-285.   

Wu YS, Lu HL, Huang X, Liu DH, Meng XM, Guo X, Kim YC, Xu WX. (通讯作者)   Diabetes-induced loss of gastric ICC accompanied by up-regulation of natriuretic peptide signaling pathways in STZ-induced diabetic mice   Peptides   2013   40(1):104-111   

Xin Guo, Xu Huang, Yi-song Wu, Dong-hai Liu, Hong-li Lu, Yong-chul Kim, Wen-xie Xu (通讯作者)   Down-Regulation of Hydrogen Sulfide Biosynthesis Accompanies Murine Interstitial Cells of Cajal Dysfunction in Partial Ileal Obstruction   PLOS ONE   2012   7(11): e48249   

Cai YL, Sun Q, Huang X, Jiang JZ, Zhang MH, Piao LH, Jin Z, Xu WX. (通讯作者)   cGMP-PDE3-cAMP signal pathway involved in the inhibitory effect of CNP on gastric motility in rat.    Regul Pept.   2012   24. S0167-0115   

Yan-fei Han a, Xu Huang a, Xin Guo, Yi-song Wu, Dong-hai Liu, Hong-li Lu, Young-chul Kim, Wen-xie Xu (通讯作者)   Evidence that endogenous hydrogen sulfide exerts an excitatory effect on gastric 3 motility in mice   European Journal of Pharmacology   2011   673 : 85–95   

Lu HL, Wang ZY, Huang X, Han YF, Wu YS, Guo X, Kim YC, Xu WX. (通讯作者)   Excitatory regulation of angiotensin II on gastric motility and its mechanism in guinea pig.    Regul Pept.   2011   167:170-176   

Qiu ZX, Mei B, Wu YS, Huang X, Wang ZY, Han YF, Lu HL, Kim YC, Xu WX. (通讯作者)   Atrial natriuretic peptide signal pathway upregulated in stomach of streptozotocin-induced diabetic mice.   World J Gastroenterol   2010   16(1): 48-55.   

Wang ZY, Han YR, Huang Xu, Peng Zhao, Lu HL, Guo X, Kim YC, Xu WX. (通讯作者)   Pacemaking activity is regulated by membrane stretch via the CICR pathway in cultured interstitial cells of Cajal from murine intestine.    Biomechanics   2010   43:2214–2220.   

Wang ZY, Han YF, Huang X, Lu HL, Guo X, Kim YC, Xu WX. (通讯作者)   Actin microfilament involved in regulation of pacemaking activity in cultured interstitial cells of Cajal from murine intestine.   Membr Biol.   2010   234(3):217-25.   

Huang X, Zhao D, Wang ZY, Zhang ML, Yan ZQ, Han YF, Lu HL, Xu WX (通讯作者), Jiang ZL.    Spontaneous rhythmic inward currents recorded in interstitial cells of rabbit portal vein.   Biochem Biophys   2010   57: 77-85.   

Huang X, Zhao D, Wang ZY, Zhang ML, Yan ZQ, Han YF, Xu WX (通讯作者), Jiang ZL.   The properties of spontaneous transient inward currents of interstitial cells in rabbit portal vein.    Eur J Pharmacol   2010   643:63–69   

Xu DY, Liu L, Cai YL, Qiu ZX, Xu WX. (通讯作者)   Natriuretic Peptide-Dependent cGMP Signal Pathway Potentiated the Relaxation of Gastric Smooth Muscle in Streptozotocin-Induced Diabetic Rats.   Dig Dis Sci   2010   55:589–595.   

Zhao P, Xu H, Wang ZW, Qiu ZX, Han YF, Lu HL, Kim YC, Xu WX (通讯作者)   Dual effect of exogenous hydrogen sulfide on the spontaneous contraction of gastric smooth muscle in guinea-pig.    Eu J Pharmacol   2009   616: 223–228   

Xu HY, Huang X, Yang M, Sun JB, Piao LH, Zhang Y, Gao L, Xu WX (通讯作者)   The Effect of C-Type Natriuretic peptide on Delayed Rectifier Potassium Currents in Gastric Antral Circular Myocytes of the Guinea-Pig.    Physiol Res.   2008   57:55-62.   

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